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1). The glutamate is converted by glutaminase to glutamine, an ATP requiring reaction (3), with the glutamine transported to the presynaptic terminal as an inert compound that won't cause excitotoxicity. 2). The uptake of glutamate triggers glucose uptake into the astrocyte, which is glycolytically converted to lactate, producing two molecules of ATP. These ATP fuel the re-equilibration after glutamate uptake and the lactate is shuttled to the neurones for oxidative metabolism. There's inadequate space in this assessment to provide an in depth analysis of the ANLSH however there are numerous opinions, which either help or contest the idea (Korf, 2006 \ No newline at end of file